Dynamic PET-facilitated modeling and high-dose rifampin regimens for Staphylococcus aureus orthopedic implant–associated infections

Author:

Gordon Oren12ORCID,Lee Donald E.3ORCID,Liu Bessie4,Langevin Brooke3,Ordonez Alvaro A.12ORCID,Dikeman Dustin A.5ORCID,Shafiq Babar6ORCID,Thompson John M.6ORCID,Sponseller Paul D.6ORCID,Flavahan Kelly12,Lodge Martin A.7ORCID,Rowe Steven P.7ORCID,Dannals Robert F.7ORCID,Ruiz-Bedoya Camilo A.12ORCID,Read Timothy D.8ORCID,Peloquin Charles A.9ORCID,Archer Nathan K.5ORCID,Miller Lloyd S.510ORCID,Davis Kimberly M.4ORCID,Gobburu Jogarao V. S.3ORCID,Jain Sanjay K.127ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3. Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.

4. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

5. Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

6. Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

7. Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

8. Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA 30322, USA.

9. Infectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.

10. Immunology, Janssen Research and Development, Spring House, PA 19477, USA.

Abstract

Current rifampin dosing achieves subtherapeutic concentrations within S. aureus –infected bone, which can be overcome with higher rifampin dosing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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