STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade-Reference-Cited by-同舟云学术

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Published:2015-04-15 Issue:283 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Fu Juan¹,Kanne David B.²,Leong Meredith²,Glickman Laura Hix²,McWhirter Sarah M.²,Lemmens Edward²,Mechette Ken²,Leong Justin J.²,Lauer Peter²,Liu Weiqun²,Sivick Kelsey E.²,Zeng Qi¹,Soares Kevin C.³,Zheng Lei³,Portnoy Daniel A.⁴,Woodward Joshua J.⁵,Pardoll Drew M.³,Dubensky Thomas W.²,Kim Young¹³

Affiliation:

1. Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA.

2. Aduro Biotech Inc., Berkeley, CA 94710, USA.

3. Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

4. Department of Molecular and Cell Biology and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.

5. Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Abstract

Cyclic dinucleotide formulated cancer vaccine combined with PD-1 blockade can induce regression of tumors that do not express PD-L1 constitutively.

Funder

NIH

Melanoma Research Alliance

Viragh Foundation

Skip Viragh Pancreatic Cancer Center at Johns Hopkins

National Cancer Institute Specialized Programs of Research Excellence (SPORE)

Aduro Biotech Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

1. Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2. Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

3. Decisions About Dendritic Cells: Past, Present, and Future

4. Dendritic Cells: Master Regulators of the Immune Response

5. Adjuvants for cancer vaccines

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