Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo-Reference-Cited by-同舟云学术

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

Published:2015-04-22 Issue:284 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cuende Julia¹,Liénart Stéphanie¹,Dedobbeleer Olivier¹,van der Woning Bas²,De Boeck Gitte²,Stockis Julie¹,Huygens Caroline¹,Colau Didier³,Somja Joan⁴,Delvenne Philippe⁴,Hannon Muriel⁴,Baron Frédéric⁴,Dumoutier Laure³,Renauld Jean-Christophe³,De Haard Hans²,Saunders Michael²,Coulie Pierre G.¹,Lucas Sophie¹

Affiliation:

1. de Duve Institute, Université catholique de Louvain, and WELBIO, B1200 Brussels, Belgium.

2. arGEN-X BVBA, Technologiepark 30, B9052 Zwijnaarde, Gent, Belgium.

3. Ludwig Cancer Research, B1200 Brussels, Belgium.

4. Department of Pathology, University Hospital of Liège, and Interdisciplinary Cluster of Applied Genoproteomics (GIGA), Laboratory of Experimental Pathology, University of Liège, B4000 Liège, Belgium.

Abstract

Monoclonal antibodies that inhibit human T reg function in vivo may be used therapeutically in cancer or infections.

Funder

Fondation contre le Cancer (Belgium)

Fonds J. Maisin (Belgium)

Fonds National pour la Recherche Scientifique

Belgian Cancer Plan

Fonds National pour la Recherche Scientifique (Belgium)

Fondation Salus Sanguinis (Belgium)

Actions de Recherche Concertees

Publisher

American Association for the Advancement of Science (AAAS)