More Velcro for the TGF-β1 straitjacket: A new antibody straps latent TGF-β1 to the matrix-Reference-Cited by-同舟云学术

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More Velcro for the TGF-β1 straitjacket: A new antibody straps latent TGF-β1 to the matrix

Published:2024-07-09 Issue:844 Volume:17 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hinz Boris¹²^ORCID

Affiliation:

1. Keenan Research Institute for Biomedical Science of St. Michael’s Hospital, Toronto, Ontario, Canada.

2. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Abstract

In this issue of Science Signaling , Jackson et al. present a new antibody strategy to—quite literally—strap transforming growth factor–β1 (TGF-β1) to latent complexes in the extracellular matrix. The antibody has no effect on latent TGF-β1 presented on the surface of immune cells and thus allows targeting of the detrimental effects of TGF-β1 in fibrosis without affecting its beneficial immune-suppressing activities.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/scisignal.ado5279

Reference10 articles.

1. TGF-β1 – A truly transforming growth factor in fibrosis and immunity

2. An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

3. Latent TGF-β structure and activation

4. Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

5. Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

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