Hurdles in therapy with regulatory T cells-Reference-Cited by-同舟云学术

Hurdles in therapy with regulatory T cells

Published:2015-09-09 Issue:304 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Trzonkowski Piotr¹²,Bacchetta Rosa³,Battaglia Manuela⁴,Berglund David⁵,Bohnenkamp Hermann Richard⁶,ten Brinke Anja⁷,Bushell Andrew⁸,Cools Nathalie⁹,Geissler Edward K.¹⁰,Gregori Silvia¹¹,Marieke van Ham S.⁷,Hilkens Catharien¹²,Hutchinson James A.¹³,Lombardi Giovanna¹⁴,Madrigal J. Alejandro¹⁵,Marek-Trzonkowska Natalia¹⁶,Martinez-Caceres Eva M.¹⁷,Roncarolo Maria Grazia¹¹¹⁸,Sanchez-Ramon Silvia¹⁹,Saudemont Aurore¹⁵,Sawitzki Birgit²⁰

Affiliation:

1. Medical University of Gdansk, Department of Clinical Immunology and Transplantology, Debinki 7, 80-952 Gdansk, Poland.

2. All authors equally contributed to this work.

3. Department of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Standford, California, USA.

4. Diabetes Research Institute (DRI), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

5. Uppsala University, Department of Immunology, Genetics and Pathology; Section of Clinical Immunology, Rudbeck Laboratory, 751 85 Uppsala, Sweden.

6. Miltenyi Biotec GmbH, Clinical Business, Friedrich-Ebert-Straße 68, 51429 Bergisch Gladbach, Germany.

7. Department of Immunopathology, Sanquin Blood Supply, Division Research, Plesmanlaan 125, 1066 CX Amsterdam, Netherland and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

8. Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.

9. Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp University Hospital (UZA), Wilrijkstraat 10, B-2650 Edegem, Belgium.

10. Division of Experimental Surgery, Department of Surgery, University Hospital Regensburg, Regensburg, Bavaria, 93053, Germany.

11. San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.

12. Institute of Cellular Medicine, Newcastle University NE2 4HH, UK.

13. Division of Experimental Surgery, Department of Surgery, University Hospital Regensburg, Regensburg, 93053, Bavaria, Germany.

14. Medical Research Council (MRC) Centre in Transplantation, King’s College London, Guy’s Hospital, Great Maze Pond, London SE1 9RT, UK.

15. Anthony Nolan Research Institute, University College London (UCL) Royal Free Hospital Campus, 77c Fleet Road, London NW3 2QG, UK.

16. Department of Family Medicine, Medical University of Gdańsk, Ul. Dębinki 2 80-210 Gdańsk, Poland.

17. Immunology Division, Germans Trias i Pujol University Hospital. Campus Can Ruti. Department of Cellular Biology, Physiology, and Immunology, Universitat Autònoma Barcelona 08916, Badalona, Barcelona, Spain.

18. Department of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, California, USA.

19. Departamento de Inmunología Clínica, Hospital Clínico San Carlos, Calle Profesor Martín Lagos S/N, E- 28040 Madrid, Spain.

20. AG Transplantationstoleranz, Charite Universitätsmedizin, Institut für Med. Imunologie, Augustenburgerplatz 1, 13353 Berlin, Germany.

Abstract

Translating regulatory T cell therapy to the clinic in Europe is making progress but has remaining challenges.

Funder

EU-FP7

Fund for Scientific Research

National Science Centre, Poland

Instituto de Salud Carlos III

National Centre for Research and Development, Poland

Swedish Medical Research Council

Polish Ministry of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. Administration of CD4+CD25highCD127- Regulatory T Cells Preserves -Cell Function in Type 1 Diabetes in Children

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