Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

Author:

Doody Karen M.1,Stanford Stephanie M.1,Sacchetti Cristiano1,D. Svensson Mattias N.1,Coles Charlotte H.2,Mitakidis Nikolaos2,Kiosses William B.3,Bartok Beatrix4,Fos Camille1,Cory Esther5,Sah Robert L.5,Liu-Bryan Ru46,Boyle David L.4,Arnett Heather A.7,Mustelin Tomas8,Corr Maripat4,Esko Jeffrey D.9,Tremblay Michel L.101112,Firestein Gary S.4,Aricescu A. Radu2,Bottini Nunzio1

Affiliation:

1. Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

2. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

3. Core Microscopy, Scripps Research Institute, La Jolla, CA 92037, USA.

4. Division of Rheumatology, Allergy and Immunology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.

5. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

6. Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, San Diego, CA 92161, USA.

7. Inflammation Research, Amgen Washington, Seattle, WA 98119, USA.

8. Research, MedImmune, AstraZeneca, One Medimmune Way, Gaithersburg, MD 20878, USA.

9. Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA.

10. Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, Canada.

11. Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.

12. Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec H3A 1A3, Canada.

Abstract

Targeting joint-lining fibroblast-like synoviocytes reduces the severity of arthritis.

Funder

NIH

Juvenile Diabetes Research Foundation

Canadian Institutes for Health Research Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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