PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration-Reference-Cited by-同舟云学术

PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Published:2009-10-23 Issue:5952 Volume:326 Page:592-596
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shen Yingjie¹,Tenney Alan P.¹,Busch Sarah A.²,Horn Kevin P.²,Cuascut Fernando X.²,Liu Kai³,He Zhigang³,Silver Jerry²,Flanagan John G.¹

Affiliation:

1. Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA.

3. Division of Neuroscience, Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Toward Neuronal Regeneration Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage. The scar tissue contains sulfated proteoglycans that seem to inhibit axon regeneration. Shen et al. (p. 592 , published online 15 October) have now identified a protein tyrosine phosphatase (PTP) in mouse neuronal membranes that functions as a receptor for the proteoglycans. Neurons that lacked this particular PTP showed improved regeneration. Regeneration remained incomplete, presumably due to other inhibitory factors in the way of complete axon regeneration.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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