Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

Author:

Schechter Melissa E.1ORCID,Andrade Bruno B.23456ORCID,He Tianyu78ORCID,Richter George Haret7,Tosh Kevin W.2ORCID,Policicchio Benjamin B.79ORCID,Singh Amrit10ORCID,Raehtz Kevin D.711,Sheikh Virginia10ORCID,Ma Dongying12,Brocca-Cofano Egidio78ORCID,Apetrei Cristian711ORCID,Tracy Russel13ORCID,Ribeiro Ruy M.1415ORCID,Sher Alan2ORCID,Francischetti Ivo M. B.12ORCID,Pandrea Ivona78,Sereti Irini10ORCID

Affiliation:

1. Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.

2. Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil.

4. Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Instituto Brasileiro para a Investigação da Tuberculose, Fundação José Silveira, Salvador 40210-320, Brazil.

5. Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

6. Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

7. Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

8. Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

9. Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.

10. HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

11. Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

12. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

13. Department of Pathology and Laboratory Medicine, The Robert Larner, M.D. College of Medicine University of Vermont, Burlington, VT 05405, USA.

14. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.

15. Laboratório de Biomatemática, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal.

Abstract

Activated monocytes in blood promote chronic inflammation and persistent coagulation in HIV-infected patients and SIV-infected macaques.

Funder

NIH Clinical Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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