ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis

Author:

Song Eun Kyung12ORCID,Jeon Jimin345ORCID,Jang Dong Gil1ORCID,Kim Ha Eun1ORCID,Sim Hyo Jung1ORCID,Kwon Keun Yeong1ORCID,Medina-Ruiz Sofia6,Jang Hyun-Jun1ORCID,Lee Ah Reum1,Rho Jun Gi7,Lee Hyun-Shik8,Kim Seok Jung9ORCID,Park Chan Young1ORCID,Myung Kyungjae2,Kim Wook7,Kwon Taejoon1ORCID,Yang Siyoung345ORCID,Park Tae Joo12ORCID

Affiliation:

1. School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.

2. Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.

3. Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.

4. Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea.

5. CIRNO, Sungkyunkwan University, Suwon 16419, Republic of Korea.

6. Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

7. Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.

8. KNU-Center for Nonlinear Dynamics, CMRI, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.

9. Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Abstract

ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.

Funder

Ulsan National Institute of Science and Technology

Ajou University

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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