Integrin α 4 β 7 expression on peripheral blood CD4 + T cells predicts HIV acquisition and disease progression outcomes-Reference-Cited by-同舟云学术

Integrin α 4 β 7 expression on peripheral blood CD4 + T cells predicts HIV acquisition and disease progression outcomes

Published:2018-01-24 Issue:425 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sivro Aida¹²^ORCID,Schuetz Alexandra³⁴⁵^ORCID,Sheward Daniel⁶,Joag Vineet⁷,Yegorov Sergey⁷^ORCID,Liebenberg Lenine J.¹^ORCID,Yende-Zuma Nonhlanhla¹,Stalker Andrew²^ORCID,Mwatelah Ruth S.²^ORCID,Selhorst Philippe⁶,Garrett Nigel¹^ORCID,Samsunder Natasha¹,Balgobin Anisha¹,Nawaz Fatima⁸,Cicala Claudia⁸,Arthos James⁸,Fauci Anthony S.⁸,Anzala Aggrey Omu⁹¹⁰,Kimani Joshua²¹⁰^ORCID,Bagaya Bernard S.¹¹¹²^ORCID,Kiwanuka Noah¹¹¹³,Williamson Carolyn¹⁶^ORCID,Kaul Rupert⁷¹⁴¹⁵^ORCID,Passmore Jo-Ann S.¹⁶¹⁶^ORCID,Phanuphak Nittaya¹⁷^ORCID,Ananworanich Jintanat⁴¹⁷¹⁸^ORCID,Ansari Aftab¹⁹^ORCID,Abdool Karim Quarraisha¹²⁰^ORCID,Abdool Karim Salim S.¹²⁰^ORCID,McKinnon Lyle R.¹²¹⁰^ORCID,

Affiliation:

1. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.

2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

3. Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.

4. U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute, Silver Spring, MD 20817, USA.

5. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

6. Division of Medical Virology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service, Cape Town 7925, South Africa.

7. Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

8. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892–9806, USA.

9. Kenyan AIDS Vaccine Initiative, Nairobi 00202, Kenya.

10. Department of Medical Microbiology, University of Nairobi, Nairobi 00202, Kenya.

11. Uganda Virus Research Institute–International AIDS Vaccine Initiative HIV Vaccine Program, Plot 51-59, Nakiwogo Road, Entebbe, Uganda.

12. Department of Epidemiology and Biostatistics, Makerere University, P.O. Box 7062, Kampala, Uganda.

13. Department of Immunology and Molecular Biology, Makerere University, P.O. Box 7062, Kampala, Uganda.

14. Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

15. University Health Network, Toronto, Ontario M5G IL7, Canada.

16. National Health Laboratory Services, Cape Town 8005, South Africa.

17. South East Asia Research Collaboration in HIV (SEARCH), The Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

18. University of Amsterdam, 1000 GG Amsterdam, Netherlands.

19. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

20. Department of Epidemiology, Columbia University, New York, NY 10032, USA.

Abstract

CD4 + T cells expressing α 4 β 7 play an important role in HIV pathogenesis.

Funder

NIH R21

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference48 articles.

1. Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection

2. Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group.

3. Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract

4. Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection

5. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

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