Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation-Reference-Cited by-同舟云学术

Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation

Published:2018-08-29 Issue:456 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

López-Alonso Inés¹²³⁴^ORCID,Blázquez-Prieto Jorge¹²³⁴,Amado-Rodríguez Laura¹³⁴^ORCID,González-López Adrián⁴⁵^ORCID,Astudillo Aurora⁶⁷^ORCID,Sánchez Manuel⁸,Huidobro Covadonga¹³⁴^ORCID,López-Martínez Cecilia²³,dos Santos Claudia C.⁹,Albaiceta Guillermo M.¹²³⁴^ORCID

Affiliation:

1. Área del Corazón, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.

2. Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, 33005 Oviedo, Spain.

3. Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.

4. Centro de Investigación Biomédica En Red–Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain.

5. Department of Anesthesiology and Operative Intensive Care Medicine, Charité Universitätsmedizin, 10117 Berlin, Germany.

6. Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.

7. Departamento de Cirugía y Especialidades Médicoquirúrgicas, Universidad de Oviedo, 33005 Oviedo, Spain.

8. Área de Farmacología, Departamento de Medicina, Universidad de Oviedo, 33005 Oviedo, Spain.

9. Interdepartmental Division of Critical Care, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1WB, Canada.

Abstract

Mechanical stretch sensed by the nuclear membranes of lung alveoli triggers cell death that can be prevented by maintaining nuclear membrane stiffness.

Funder

Instituto de Salud Carlos III

Fundación para el fomento en Asturias de la Investigación Científica Aplicada y la Tecnología

Fundación Asturcor

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

1. Matrix Elasticity Directs Stem Cell Lineage Specification

2. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

3. Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation