Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation-Reference-Cited by-同舟云学术

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Published:2013-08-30 Issue:6149 Volume:341 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Swift Joe¹,Ivanovska Irena L.¹,Buxboim Amnon¹,Harada Takamasa¹,Dingal P. C. Dave P.¹,Pinter Joel¹,Pajerowski J. David¹,Spinler Kyle R.¹,Shin Jae-Won¹,Tewari Manorama¹,Rehfeldt Florian¹,Speicher David W.²,Discher Dennis E.¹²

Affiliation:

1. Molecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. The Center for Systems and Computational Biology, Wistar Institute, Philadelphia, PA 19104, USA.

Abstract

Lamins and Tissue Stiffness Microenvironment can influence cell fate and behavior; for example, extracellular matrix (ECM) stiffness increases cell proliferation, and ECM rigidity induces disorders in tissue morphogenesis by increasing cell tension. Swift et al. ( 1240104 ; see the Perspective by Bainer and Weaver ) used proteomics to identify molecules that are mechanical sensors for tissue elasticity in the nucleus and discovered that expression of lamin-A levels apparently functions as a “mechanostat.”

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference123 articles.

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