Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates-Reference-Cited by-同舟云学术

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Published:2021-08-18 Issue:607 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Francica Joseph R.¹^ORCID,Flynn Barbara J.¹,Foulds Kathryn E.¹^ORCID,Noe Amy T.¹^ORCID,Werner Anne P.¹,Moore Ian N.¹^ORCID,Gagne Matthew¹^ORCID,Johnston Timothy S.¹^ORCID,Tucker Courtney¹,Davis Rachel L.¹,Flach Britta¹,O’Connell Sarah¹,Andrew Shayne F.¹^ORCID,Lamb Evan¹^ORCID,Flebbe Dillon R.¹,Nurmukhambetova Saule T.¹,Donaldson Mitzi M.¹,Todd John-Paul M.¹^ORCID,Zhu Alex Lee²³^ORCID,Atyeo Caroline²⁴^ORCID,Fischinger Stephanie²³^ORCID,Gorman Matthew J²,Shin Sally²^ORCID,Edara Venkata Viswanadh⁵⁶⁷^ORCID,Floyd Katharine⁵⁶⁷^ORCID,Lai Lilin⁵⁶⁷,Boyoglu-Barnum Seyhan¹,Van De Wetering Renee¹^ORCID,Tylor Alida¹^ORCID,McCarthy Elizabeth¹^ORCID,Lecouturier Valerie⁸^ORCID,Ruiz Sophie⁸^ORCID,Berry Catherine⁸^ORCID,Tibbitts Timothy⁹^ORCID,Andersen Hanne¹⁰^ORCID,Cook Anthony¹⁰,Dodson Alan¹⁰^ORCID,Pessaint Laurent¹⁰^ORCID,Van Ry Alex¹⁰^ORCID,Koutsoukos Marguerite¹¹^ORCID,Gutzeit Cindy¹²,Teng I.-Ting¹,Zhou Tongqing¹^ORCID,Li Dapeng¹³,Haynes Barton F.¹³^ORCID,Kwong Peter D.¹^ORCID,McDermott Adrian¹^ORCID,Lewis Mark G.¹⁰^ORCID,Fu Tong Ming⁹^ORCID,Chicz Roman⁹,van der Most Robbert¹²^ORCID,Corbett Kizzmekia S.¹^ORCID,Suthar Mehul S.⁵⁶⁷^ORCID,Alter Galit²^ORCID,Roederer Mario¹^ORCID,Sullivan Nancy J.¹^ORCID,Douek Daniel C.¹,Graham Barney S.¹^ORCID,Casimiro Danilo⁹,Seder Robert A.¹^ORCID

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

2. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

3. Ph.D. program in Immunology and Virology, University of Duisburg-Essen, Essen, Germany.

4. Ph.D. program in Virology, Division of Medical Sciences, Harvard University, Boston, MA 02138, USA.

5. Centers for Childhood Infections and Vaccines, Children’s Healthcare of Atlanta and Emory University, Department of Pediatrics, Atlanta, GA, 30329, USA.

6. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA.

7. Yerkes National Primate Research Center, Atlanta, GA 30329, USA.

8. Sanofi Pasteur, Marcy l'Etoile, France.

9. Sanofi Pasteur, 38 Sidney Street, Cambridge, MA 02139, USA.

10. Bioqual Inc., Rockville, MD 20850, USA.

11. GSK, Wavre, Belgium.

12. GSK, Rixensart, Belgium.

13. Duke Human Vaccine Institute, Duke University, Durham, NC 27708, USA.

Abstract

Vaccination of nonhuman primates with SARS-CoV-2 spike trimers and AS03 adjuvant induces neutralizing antibodies sufficient to protect from disease.

Funder

National Institutes of Health