A Host-Based RT-PCR Gene Expression Signature to Identify Acute Respiratory Viral Infection-Reference-Cited by-同舟云学术

A Host-Based RT-PCR Gene Expression Signature to Identify Acute Respiratory Viral Infection

Published:2013-09-18 Issue:203 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zaas Aimee K.¹²,Burke Thomas¹,Chen Minhua³,McClain Micah¹²,Nicholson Bradly⁴,Veldman Timothy¹,Tsalik Ephraim L.¹²⁴,Fowler Vance²,Rivers Emanuel P.⁵,Otero Ronny⁵,Kingsmore Stephen F.⁶,Voora Deepak¹²,Lucas Joseph¹,Hero Alfred O.⁷,Carin Lawrence⁸,Woods Christopher W.¹²⁴,Ginsburg Geoffrey S.¹²

Affiliation:

1. Institute for Genome Sciences and Policy, Duke University School of Medicine, Durham, NC 27710, USA.

2. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

3. Departments of Statistics and Computer Science, University of Chicago, Chicago, IL 60637, USA.

4. Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.

5. Department of Emergency Medicine, Henry Ford Health Center, Detroit, MI 48202, USA.

6. Center for Pediatric Genomic Medicine, Children’s Mercy Hospital, Kansas City, MO 64108, USA.

7. Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.

8. Department of Electrical and Computer Engineering, Duke University, Durham, NC 27710, USA.

Abstract

To improve the diagnosis of respiratory viral infection, a multiplex RT-PCR assay based on the host response was derived from experimentally infected subjects and validated in patients with febrile illness.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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