Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group

Author:

Hanson Kimberly E12,Banerjee Ritu3,Doernberg Sarah B4,Evans Scott R5,Komarow Lauren6,Satlin Michael J7,Schwager Nyssa8,Simner Patricia J9,Tillekeratne L Gayani1011,Patel Robin1213,Tsalik Ephraim,Abbenante Erin,Baum Keri,Souli Maria,Mocka Elizabeth,Hopkins Deborah,Giri Abhigya,Zeng Lijuan,Greenwood-Quaintance Kerryl,Dodd Andrew,Booth Grant,Li Yixuan,Waller Jason,Raza Praneeta,Sund Zoe,Wickward Cathy,Zeng Lijuan,Dai Weixiao,Hamasaki Toshimitsu,Ghazaryan Varduhi,Raterman Erica,Samuel Tamika,Lee Marina,

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University of Utah , Salt Lake City, Utah , USA

2. Division of Clinical Microbiology, Department of Pathology, University of Utah , Salt Lake City, Utah , USA

3. Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee , USA

4. Division of Infectious Diseases, Department of Medicine, University of California, San Francisco , San Francisco, California , USA

5. Department of Biostatistics, George Washington University , Washington, DC , USA

6. George Washington University Biostatistics Center , Rockville, Maryland , USA

7. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine , New York, New York , USA

8. Duke Clinical Research Institute, Duke University School of Medicine , Durham, North Carolina , USA

9. Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

10. Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine , Durham, North Carolina , USA

11. Duke Global Health Institute, Duke University , Durham, North Carolina , USA

12. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, Minnesota , USA

13. Division of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic , Rochester, Minnesota , USA

Abstract

Abstract The advancement of infectious disease diagnostics, along with studies devoted to infections caused by gram-negative and gram-positive bacteria, is a top scientific priority of the Antibacterial Resistance Leadership Group (ARLG). Diagnostic tests for infectious diseases are rapidly evolving and improving. However, the availability of rapid tests designed to determine antibacterial resistance or susceptibility directly in clinical specimens remains limited, especially for gram-negative organisms. Additionally, the clinical impact of many new tests, including an understanding of how best to use them to inform optimal antibiotic prescribing, remains to be defined. This review summarizes the recent work of the ARLG toward addressing these unmet needs in the diagnostics field and describes future directions for clinical research aimed at curbing the threat of antibiotic-resistant bacterial infections.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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