Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension-Reference-Cited by-同舟云学术

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

Published:2010-08-11 Issue:44 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sutendra Gopinath¹²,Bonnet Sebastien¹³,Rochefort Gael¹,Haromy Alois¹²,Folmes Karalyn D.²,Lopaschuk Gary D.²,Dyck Jason R. B.²,Michelakis Evangelos D.¹²

Affiliation:

1. Pulmonary Hypertension Program, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

2. Cardiovascular Research Center, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

3. Department of Medicine, Laval University, Quebec City, Quebec, Canada G1R 2J6.

Abstract

The overgrowth of vascular cells that causes pulmonary hypertension can be prevented in mice by inhibiting a metabolic shift toward glycolysis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension

2. Basic Science of Pulmonary Arterial Hypertension for Clinicians

3. A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

4. Metabolic Modulation of Glioblastoma with Dichloroacetate

5. Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?

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