TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling-Reference-Cited by-同舟云学术

TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

Published:2014-03-12 Issue:227 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cooley Brian C.¹,Nevado Jose²³,Mellad Jason⁴,Yang Dan³,St. Hilaire Cynthia³,Negro Alejandra³,Fang Fang³,Chen Guibin³,San Hong³,Walts Avram D.³,Schwartzbeck Robin L.³,Taylor Brandi³,Lanzer Jan D.³,Wragg Andrew³⁴,Elagha Abdalla³⁵,Beltran Leilani E.³,Berry Colin³⁶,Feil Robert⁷,Virmani Renu⁸,Ladich Elena⁸,Kovacic Jason C.³⁹,Boehm Manfred³

Affiliation:

1. Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

2. National Institutes of Health–University of the Philippines College of Medicine, Manila 1000, Philippines.

3. Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

4. William Harvey Research Institute, Barts and the London NHS Trust, London EC1M 6BQ, UK.

5. Cardiovascular Department, Faculty of Medicine, Cairo University, Cairo 11559, Egypt.

6. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, Scotland, UK.

7. Interfaculty Institute of Biochemistry, Universität Tübingen, 72074 Tübingen, Germany.

8. CVPath Institute Inc., Gaithersburg, MD 20878, USA.

9. The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

In vivo endothelial cell fate mapping demonstrates that TGF-β signaling is a central pathway regulating the endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. p21Cip1 modulates arterial wound repair through the stromal cell–derived factor-1/CXCR4 axis in mice.;Olive M.;J. Clin. Invest.,2008

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