Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action

Author:

Lindtner Claudia1,Scherer Thomas12,Zielinski Elizabeth1,Filatova Nika1,Fasshauer Martin1,Tonks Nicholas K.3,Puchowicz Michelle4,Buettner Christoph15

Affiliation:

1. Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029–6574, USA.

2. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

3. Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

4. Mouse Metabolic Phenotyping Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

5. Department of Neuroscience and Diabetes, Obesity and Metabolism Institute (DOMI), Icahn School of Medicine at Mount Sinai, New York, NY 10029–6574, USA.

Abstract

Rats given alcohol to simulate binge drinking exhibit the first signs of diabetes, a result of altered insulin action in the brain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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