mAbs and Ad-Vectored IFN-α Therapy Rescue Ebola-Infected Nonhuman Primates When Administered After the Detection of Viremia and Symptoms-Reference-Cited by-同舟云学术

mAbs and Ad-Vectored IFN-α Therapy Rescue Ebola-Infected Nonhuman Primates When Administered After the Detection of Viremia and Symptoms

Author:

Qiu Xiangguo¹,Wong Gary¹²,Fernando Lisa¹,Audet Jonathan¹²,Bello Alexander¹²,Strong Jim¹,Alimonti Judie B.¹²,Kobinger Gary P.¹²³⁴

Affiliation:

1. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

3. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

4. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

Monoclonal antibodies and adenovirus-vectored IFN-α extend the treatment window for Zaire ebolavirus in macaques.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference32 articles.

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