Plasmodium falciparum transmission stages accumulate in the human bone marrow

Author:

Joice Regina1,Nilsson Sandra K.1,Montgomery Jacqui23,Dankwa Selasi1,Egan Elizabeth1,Morahan Belinda4,Seydel Karl B.56,Bertuccini Lucia7,Alano Pietro7,Williamson Kim C.4,Duraisingh Manoj T.1,Taylor Terrie E.56,Milner Danny A.158,Marti Matthias1

Affiliation:

1. Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.

2. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P. O. Box 30096, Chichiri, Blantyre 3, Malawi.

3. Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, UK.

4. Department of Biology, Loyola University, 1032 West Sheridan Road, Chicago, IL 60660, USA.

5. Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre 3, Malawi.

6. College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.

7. Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena n. 299, 00191 Rome, Italy.

8. Department of Pathology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA.

Abstract

Sexual stages of the human malaria parasite Plasmodium falciparum use the hematopoietic system of the bone marrow as a developmental niche.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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