KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival-Reference-Cited by-同舟云学术

KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival

Published:2013-01-23 Issue:169 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hatami Raheleh¹,Sieuwerts Anieta M.²,Izadmehr Sudeh¹,Yao Zhong³,Qiao Rui Fang³,Papa Luena⁴,Look Maxime P.²,Smid Marcel²,Ohlssen Jessica¹,Levine Alice C.⁴,Germain Doris⁴,Burstein David⁵,Kirschenbaum Alexander⁶,DiFeo Analisa⁷,Foekens John A.²,Narla Goutham¹⁴⁸

Affiliation:

1. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

2. Department of Medical Oncology, Erasmus University Medical Center and Cancer Genomics Center, 3015 GE Rotterdam, Netherlands.

3. Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

4. Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

5. Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.

6. Department of Urology, Mount Sinai School of Medicine, New York, NY 10029, USA.

7. Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

8. Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Abstract

The KLF6-SV1 splice variant is associated with poor prognosis in early-stage human breast cancer and drives metastasis through the regulation of an EMT-like program in culture and in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference93 articles.

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5. Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

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