Replacing the Enzyme α- l -Iduronidase at Birth Ameliorates Symptoms in the Brain and Periphery of Dogs with Mucopolysaccharidosis Type I-Reference-Cited by-同舟云学术

Replacing the Enzyme α- l -Iduronidase at Birth Ameliorates Symptoms in the Brain and Periphery of Dogs with Mucopolysaccharidosis Type I

Published:2010-12 Issue:60 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Dierenfeld Ashley D.¹,McEntee Michael F.²,Vogler Carole A.³,Vite Charles H.⁴,Chen Agnes H.⁵,Passage Merry⁵,Le Steven⁵,Shah Sahil⁵,Jens Jackie K.¹,Snella Elizabeth M.¹,Kline Karen L.⁶,Parkes Jennifer D.⁶,Ware Wendy A.⁶,Moran Lori E.⁶,Fales-Williams Amanda J.⁷,Wengert Jane A.⁶,Whitley R. David⁶,Betts Daniel M.⁶,Boal Amy M.⁶,Riedesel Elizabeth A.⁶,Gross William⁶,Ellinwood N. Matthew¹⁶,Dickson Patricia I.⁵

Affiliation:

1. Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011–3150, USA.

2. Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.

3. Department of Pathology, St. Louis University, St. Louis, MO 63104, USA.

4. Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104–6010, USA.

5. Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, and the Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

6. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011–1250, USA.

7. Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011–1250, USA.

Abstract

Replacing the enzyme α- l -iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

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