Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys-Reference-Cited by-同舟云学术

Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

Published:2013-07-17 Issue:194 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mingozzi Federico¹,Anguela Xavier M.¹²,Pavani Giulia¹,Chen Yifeng¹²,Davidson Robert J.¹,Hui Daniel J.¹,Yazicioglu Mustafa¹,Elkouby Liron¹²,Hinderer Christian J.¹³,Faella Armida¹,Howard Carolann¹,Tai Alex¹,Podsakoff Gregory M.¹,Zhou Shangzhen¹,Basner-Tschakarjan Etiena¹,Wright John Fraser¹⁴,High Katherine A.¹²⁴

Affiliation:

1. Department of Pediatrics and Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

2. Howard Hughes Medical Institute, Philadelphia, PA 19104, USA.

3. Gene Therapy and Vaccine Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Department of Pediatrics, Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Capsid decoys enhance the efficacy of AAV vector transduction after systemic delivery in the presence of neutralizing antibodies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

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5. Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

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