mTOR inhibition improves immune function in the elderly-Reference-Cited by-同舟云学术

mTOR inhibition improves immune function in the elderly

Published:2014-12-24 Issue:268 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mannick Joan B.¹,Del Giudice Giuseppe²,Lattanzi Maria²,Valiante Nicholas M.³,Praestgaard Jens⁴,Huang Baisong¹,Lonetto Michael A.¹,Maecker Holden T.⁵,Kovarik John⁶,Carson Simon⁷,Glass David J.¹,Klickstein Lloyd B.¹

Affiliation:

1. Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

2. Novartis Vaccines and Diagnostics, 53100 Siena, Italy.

3. Novartis Vaccines and Diagnostics, Cambridge, MA 02139, USA.

4. Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA.

5. Novartis Pharmaceuticals Corporation, CH-4002 Basel, Switzerland.

6. Stanford University School of Medicine, Stanford, CA 94305–5124, USA.

7. Southern Clinical Trials, Christchurch 8024, New Zealand.

Abstract

mTOR inhibition by RAD001 improves immune responses in elderly volunteers receiving an influenza vaccination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference24 articles.

1. Preserving Youth: Does Rapamycin Deliver?

2. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

3. Rapamycin slows aging in mice

4. Late-life rapamycin treatment reverses age-related heart dysfunction

5. Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States

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