Late-life rapamycin treatment reverses age-related heart dysfunction

Author:

Flynn James M.1,O'Leary Monique N.1,Zambataro Christopher A.1,Academia Emmeline C.1,Presley Michael P.1,Garrett Brittany J.1,Zykovich Artem1,Mooney Sean D.1,Strong Randy2,Rosen Clifford J.3,Kapahi Pankaj1,Nelson Michael D.4,Kennedy Brian K.1,Melov Simon1

Affiliation:

1. Buck Institute for Research on Aging; 8001 Redwood Blvd; Novato; CA; 94945; USA

2. Department of Pharmacology and Barshop; Institute for Longevity and Aging Studies; UTHSC; South Texas Veterans Health Care System; 7703 Floyd Curl Dr; San Antonio; TX; 78229; USA

3. Center for Clinical and Translational Research; Maine Medical Center Research Institute; 81 Research Dr; Scarborough; ME; 04074; USA

4. Heart Institute, Cedars-Sinai Medical Center; 8700 Beverly Blvd; Los Angeles; CA; 90048; USA

Publisher

Wiley

Subject

Cell Biology,Ageing

Reference45 articles.

1. Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure;Aoyagi;Curr. Pharm. Des.,2011

2. Cardiac mTOR protects the heart against ischemia-reperfusion injury;Aoyagi;Am .J. Physiol. Heart Circ. Physiol.,2012

3. The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex;Astrinidis;Genes Chromosom. Cancer,2010

4. Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice;Bauer;Circ. Res.,2011

5. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition;Blagosklonny;Cell Cycle,2006

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