Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model-Reference-Cited by-同舟云学术

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

Published:2011-04-13 Issue:78 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Harvey Christopher J.¹,Thimmulappa Rajesh K.¹,Sethi Sanjay²,Kong Xiaoni¹,Yarmus Lonny³,Brown Robert H.¹³,Feller-Kopman David³,Wise Robert³,Biswal Shyam¹³

Affiliation:

1. Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.

2. Department of Medicine, University at Buffalo, Buffalo, NY 14215, USA.

3. Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Bacterial clearance in macrophages from lungs with chronic obstructive pulmonary disease is improved by stimulating the Nrf2 antioxidant signaling pathway.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

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5. Bacteria in Exacerbations of Chronic Obstructive Pulmonary Disease: Phenomenon or Epiphenomenon?

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