A multifunctional bispecific antibody protects against Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

Published:2014-11-12 Issue:262 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

DiGiandomenico Antonio¹,Keller Ashley E.¹,Gao Cuihua¹,Rainey Godfrey J.¹,Warrener Paul¹,Camara Mareia M.¹,Bonnell Jessica¹,Fleming Ryan¹,Bezabeh Binyam¹,Dimasi Nazzareno¹,Sellman Bret R.¹,Hilliard Jamese¹,Guenther Caitlin M.¹,Datta Vivekananda¹,Zhao Wei¹,Gao Changshou¹,Yu Xiang-Qing¹,Suzich JoAnn A.¹,Stover C. Kendall¹

Affiliation:

1. MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

Abstract

A new antibody platform combining anti-Psl and anti-PcrV activities provides enhanced protection and acts synergistically with antibiotics against Pseudomonas aeruginosa .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Serum therapy revisited: animal models of infection and development of passive antibody therapy

2. Return to the Past: The Case for Antibody-Based Therapies in Infectious Diseases

3. Antibiotics: Avert an impending crisis

4. The antibiotic alarm. Nature 495 141 (2013).

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