A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of <i>Pseudomonas aeruginosa</i> in Patients with Bronchiectasis-Reference-Cited by-同舟云学术

A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis

Published:2024-07-01 Issue:1 Volume:210 Page:35-46
ISSN:1073-449X
Container-title:American Journal of Respiratory and Critical Care Medicine
language:en
Short-container-title:Am J Respir Crit Care Med

Author:

Long Merete B.¹,Gilmour Amy¹,Kehl Margaret²,Tabor David E.²,Keller Ashley E.²,Warrener Paul²,Gopalakrishnan Vancheswaran²,Rosengren Sanna³,Crichton Megan L.¹,McIntosh Eve¹,Giam Yan Hui¹,Keir Holly R.¹,Brailsford Wayne⁴,Hughes Rod⁵,Belvisi Maria G.⁴,Sellman Bret R.²,DiGiandomenico Antonio²,Chalmers James D.¹

Affiliation:

1. Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom;

2. Vaccine and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland;

3. Translational Science and Experimental Medicine, Respiratory & Immunology, Respiratory and Immunology, and

4. Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and

5. Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

Funder

AstraZeneca

European Respiratory Society

Publisher

American Thoracic Society

Link

https://www.atsjournals.org/doi/pdf/10.1164/rccm.202308-1403OC

Reference34 articles.

1. Bronchiectasis

2. Heterogeneity of treatment response in bronchiectasis clinical trials

3. The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study

4. Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)

5. Adult Patients With Bronchiectasis

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2. Moving Beyond Antibiotics: Exploring the Potential of an Antivirulence Monoclonal Antibody against Pseudomonas aeruginosa in Bronchiectasis;American Journal of Respiratory and Critical Care Medicine;2024-07-01

3. A Global Effort to Stop the Vicious Vortex: A Special American Journal of Respiratory and Critical Care Medicine Issue for World Bronchiectasis Day 2024;American Journal of Respiratory and Critical Care Medicine;2024-07-01