Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma-Reference-Cited by-同舟云学术

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

Published:2013-10-30 Issue:209 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jensen Samuel A.¹,Day Emily S.²³,Ko Caroline H.²³,Hurley Lisa A.¹,Luciano Janina P.¹,Kouri Fotini M.¹,Merkel Timothy J.²³,Luthi Andrea J.²³,Patel Pinal C.²³,Cutler Joshua I.²³,Daniel Weston L.²³,Scott Alexander W.³⁴,Rotz Matthew W.²,Meade Thomas J.²⁵⁶,Giljohann David A.²³,Mirkin Chad A.²³,Stegh Alexander H.¹³

Affiliation:

1. Ken and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.

2. Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

3. International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208, USA.

4. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

5. Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.

6. Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.

Abstract

siRNA-based spherical nucleic acid (SNA) nanoparticle conjugates silence antiapoptosis signaling and impair GBM progression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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