Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies-Reference-Cited by-同舟云学术

Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies

Published:2010-11-24 Issue:59 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lanzani Chiara¹,Citterio Lorena¹,Glorioso Nicola²,Manunta Paolo¹,Tripodi Grazia³,Salvi Erika⁴⁵,Carpini Simona Delli¹,Ferrandi Mara³,Messaggio Elisabetta¹,Staessen Jan A.⁶⁷,Cusi Daniele⁵⁸⁹,Macciardi Fabio⁹¹⁰,Argiolas Giuseppe²,Valentini Giovanni¹¹,Ferrari Patrizia³,Bianchi Giuseppe¹³

Affiliation:

1. Division of Nephrology and Dialysis, Chair of Nephrology, San Raffaele Scientific Institute, Università “Vita-Salute” San Raffaele Hospital, Milan 20132, Italy.

2. Hypertension and Related Diseases Centre–Association of Urogenital Oncology, University of Sassari, Sassari 07100, Italy.

3. Prassis sigma-tau Research Institute, Settimo Milanese, Milan 20019, Italy.

4. KOS Genetic SRL, Milan 20122, Italy.

5. Department of Medicine, Surgery and Dentistry, Azienda Ospedaliera San Paolo, University of Milan, Milan 20142, Italy.

6. Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Research, University of Leuven, B-3000 Leuven, Belgium.

7. Genetic Epidemiology Unit, Department of Epidemiology, Maastricht University, 6200 MD Maastricht, Netherlands.

8. Graduate School of Nephrology, University of Milan, Milan 20142, Italy.

9. Genomics and Bioinformatics Unit, Fondazione Filarete, Milan 20139, Italy.

10. Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA.

11. Medical Department Research and Development Division, sigma-tau, Pomezia, Rome 00144, Italy.

Abstract

Five genetic variants that affect Na,K-ATPase interactions predict the blood pressure response to rostafuroxin but not to losartan and hydrochlorothiazide.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

1. Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 1: Experimental Studies

2. Genetic variations of tubular sodium reabsorption leading to “primary” hypertension: from gene polymorphism to clinical symptoms

3. Genetics of primary hypertension: The clinical impact of adducin polymorphisms

4. Circulation: Overall Regulation

5. Plasma Renin in Long-Term Diuretic Treatment of Hypertension: Effect of Discontinuation and Restarting Therapy

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