Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 1: Experimental Studies-Reference-Cited by-同舟云学术

Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 1: Experimental Studies

Published:2010-11-24 Issue:59 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ferrandi Mara¹,Molinari Isabella¹,Torielli Lucia¹,Padoani Gloria¹,Salardi Sergio¹,Rastaldi Maria Pia²,Ferrari Patrizia¹,Bianchi Giuseppe¹

Affiliation:

1. Prassis sigma-tau Research Institute, Settimo Milanese, Milan 20019, Italy.

2. Laboratorio di Ricerca Nefrologica, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico and Fondazione D’Amico per la Ricerca sulle Malattie Renali, Milan 20122, Italy.

Abstract

Rostafuroxin lowers blood pressure in rats and disrupts mutant α-adducin and ouabain–Na,K-ATPase complex interaction with the Src-SH2 domain without affecting the interaction of wild-type α-adducin or Na,K-ATPase in the absence of ouabain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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