In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous-Reference-Cited by-同舟云学术

In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

Author:

Dalkara Deniz¹,Byrne Leah C.¹,Klimczak Ryan R.²,Visel Meike²,Yin Lu³,Merigan William H.³,Flannery John G.¹²,Schaffer David V.¹²⁴

Affiliation:

1. Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720–1462, USA.

2. Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720–1462, USA.

3. Flaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, NY 14642, USA.

4. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720–1462, USA.

Abstract

Injection of a new gene therapy vector into the easily accessible vitreous transduced the entire retina and rescued disease phenotypes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

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