Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model-Reference-Cited by-同舟云学术

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

Published:2011-07-20 Issue:92 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Pleger Sven T.¹²,Shan Changguang¹²,Ksienzyk Jan²,Bekeredjian Raffi²,Boekstegers Peter³,Hinkel Rabea³,Schinkel Stefanie²,Leuchs Barbara⁴,Ludwig Jochen⁵,Qiu Gang⁶,Weber Christophe¹²,Raake Philip²,Koch Walter J.⁷,Katus Hugo A.²,Müller Oliver J.²,Most Patrick¹²⁶

Affiliation:

1. Center for Molecular and Translational Cardiology, University of Heidelberg, 69120 Heidelberg, Germany.

2. Department of Internal Medicine III, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany.

3. Internal Medicine I, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, 81377 Munich, Germany.

4. Applied Tumour Virology, German Cancer Research Center, INF 242, 69120 Heidelberg, Germany.

5. Department of Internal Medicine I and Clinical Chemistry, INF 410, University of Heidelberg, 69120 Heidelberg, Germany.

6. Laboratory for Cardiac Stem Cell and Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

7. George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

A protein that regulates cellular calcium, delivered percutaneously to the heart by gene therapy, improves cardiac function in pigs with heart failure and may also be effective in humans.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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