Intranasal Antibody Gene Transfer in Mice and Ferrets Elicits Broad Protection Against Pandemic Influenza-Reference-Cited by-同舟云学术

Intranasal Antibody Gene Transfer in Mice and Ferrets Elicits Broad Protection Against Pandemic Influenza

Author:

Limberis Maria P.¹,Adam Virginie S.¹,Wong Gary²³,Gren Jason²³,Kobasa Darwyn²³,Ross Ted M.⁴⁵,Kobinger Gary P.²³⁶,Tretiakova Anna¹,Wilson James M.¹

Affiliation:

1. Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

3. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

4. Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.

5. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA.

6. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

Abstract

Intranasal delivery of a broadly neutralizing antibody to influenza by an AAV9 vector affords complete protection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference21 articles.

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