Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice-Reference-Cited by-同舟云学术

Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

Published:2012-05-02 Issue:132 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yu Ying¹,Ricciotti Emanuela¹,Scalia Rosario²,Tang Soon Yew¹,Grant Gregory¹,Yu Zhou¹,Landesberg Gavin²,Crichton Irene³,Wu Weichen¹,Puré Ellen³,Funk Colin D.⁴,FitzGerald Garret A.¹

Affiliation:

1. Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Physiology, Temple University, Philadelphia, PA 19140, USA.

3. Wistar Institute, Philadelphia, PA 19104, USA.

4. Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario K7L 3N6, Canada.

Abstract

Deletion of vascular COX-2 predisposes mice to thrombosis and hypertension.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference29 articles.

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4. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

5. Balancing prostanoid activity in the human vascular system

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