Emerging Roles and Therapeutic Applications of Arachidonic Acid Pathways in Cardiometabolic Diseases-Reference-Cited by-同舟云学术

Emerging Roles and Therapeutic Applications of Arachidonic Acid Pathways in Cardiometabolic Diseases

Published:2024-06-21 Issue:1 Volume:135 Page:222-260
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

Hu Yufeng¹²^ORCID,Li Wei³,Cheng Xu¹²,Yang Hailong¹²^ORCID,She Zhi-Gang¹³^ORCID,Cai Jingjing¹⁴^ORCID,Li Hongliang¹³⁵^ORCID,Zhang Xiao-Jing¹⁶

Affiliation:

1. State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, China (Y.H., X.C., H.Y., Z.-G.S., J.C., H.L., X.-J.Z.).

2. Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Ganzhou, China (Y.H., X.C., H.Y.).

3. Department of Cardiology, Renmin Hospital of Wuhan University, China (W.L., Z.-G.S., H.L.).

4. Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China (J.C.).

5. Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China (H.L.).

6. School of Basic Medical Sciences, Wuhan University, China (X.-J.Z.).

Abstract

Cardiometabolic disease has become a major health burden worldwide, with sharply increasing prevalence but highly limited therapeutic interventions. Emerging evidence has revealed that arachidonic acid derivatives and pathway factors link metabolic disorders to cardiovascular risks and intimately participate in the progression and severity of cardiometabolic diseases. In this review, we systemically summarized and updated the biological functions of arachidonic acid pathways in cardiometabolic diseases, mainly focusing on heart failure, hypertension, atherosclerosis, nonalcoholic fatty liver disease, obesity, and diabetes. We further discussed the cellular and molecular mechanisms of arachidonic acid pathway–mediated regulation of cardiometabolic diseases and highlighted the emerging clinical advances to improve these pathological conditions by targeting arachidonic acid metabolites and pathway factors.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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