Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor

Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor–Like Protein

Published:2012-03-28 Issue:127 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhen Tao¹,Wu Chuan-Feng¹,Liu Ping¹,Wu Hai-Yan²,Zhou Guang-Biao³,Lu Ying¹,Liu Jian-Xiang¹,Liang Yang¹,Li Keqin Kathy¹,Wang Yue-Ying¹,Xie Yin-Yin¹,He Miao-Miao¹,Cao Huang-Ming¹,Zhang Wei-Na¹,Chen Li-Min¹⁴,Petrie Kevin⁵,Chen Sai-Juan¹²⁵,Chen Zhu¹²⁵

Affiliation:

1. State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine (SJTUSM) and Shanghai Institute of Hematology, Rui-Jin Hospital, SJTUSM, 200025 Shanghai, China.

2. Shanghai Center for Systems Biomedicine, SJTU, 200240 Shanghai, China.

3. Laboratory of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, CAS, 100101 Beijing, China.

4. Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, CAS, 201203 Shanghai, China.

5. Samuel Waxman Cancer Research Foundation Joint Translational Research Center, Shanghai Institute of Hematology, Rui-Jin Hospital, SJTUSM, 200025 Shanghai, China.

Abstract

Oridonin treats AML by generating a truncated version of the AML1-ETO oncoprotein that functions as a tumor suppressor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference32 articles.

1. Oncogenic pathways of AML1-ETO in acute myeloid leukemia: Multifaceted manipulation of marrow maturation

2. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

3. Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

4. Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice

5. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

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