Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate–Induced Cardiotoxicity

Author:

Chintalgattu Vishnu1,Rees Meredith L.2,Culver James C.3,Goel Aditya1,Jiffar Tilahu4,Zhang Jianhu5,Dunner Kenneth5,Pati Shibani6,Bankson James A.7,Pasqualini Renata8,Arap Wadih8,Bryan Nathan S.9,Taegtmeyer Heinrich2,Langley Robert R.5,Yao Hui10,Kupferman Michael E.4,Entman Mark L.11,Dickinson Mary E.3,Khakoo Aarif Y.1

Affiliation:

1. Metabolic Disorders, Amgen Inc., Research, South San Francisco, CA, USA.

2. Department of Medicine, The University of Texas Medical School at Houston, Houston, TX, USA.

3. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.

4. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

5. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

6. Department of Surgery, The University of Texas Medical School at Houston, Houston, TX, USA.

7. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

8. David H. Koch Center and Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

9. Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Houston, TX, USA.

10. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

11. Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Abstract

Sunitinib-induced cardiotoxicity is caused by depletion of coronary pericytes due to loss of PDGFR signaling; this side effect can be prevented by thalidomide.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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