Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

Author:

Cooper Oliver1,Seo Hyemyung1,Andrabi Shaida2,Guardia-Laguarta Cristina3,Graziotto John4,Sundberg Maria1,McLean Jesse R.1,Carrillo-Reid Luis5,Xie Zhong5,Osborn Teresia1,Hargus Gunnar1,Deleidi Michela1,Lawson Tristan1,Bogetofte Helle1,Perez-Torres Eduardo1,Clark Lorraine3,Moskowitz Carol3,Mazzulli Joseph4,Chen Li2,Volpicelli-Daley Laura6,Romero Norma3,Jiang Houbo7,Uitti Ryan J.8,Huang Zhigao9,Opala Grzegorz10,Scarffe Leslie A.2,Dawson Valina L.2,Klein Christine11,Feng Jian7,Ross Owen A.8,Trojanowski John Q.6,Lee Virginia M.-Y.6,Marder Karen3,Surmeier D. James5,Wszolek Zbigniew K.8,Przedborski Serge3,Krainc Dimitri4,Dawson Ted M.2,Isacson Ole1

Affiliation:

1. Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

2. Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, and Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Departments of Neurology, Psychiatry, and Pathology and Cell Biology, Sergievsky Center, Taub Institute and the Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

4. MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

5. Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

6. Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

7. Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA.

8. Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

9. University of Florida Shands, Jacksonville, FL 32209, USA.

10. Department of Neurology, Medical University of Silesia, Katowice 40-055, Poland.

11. Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, 23562 Luebeck, Germany.

Abstract

Neural cells derived from induced pluripotent stem cells from patients with genetic forms of Parkinson’s disease provide insights into disease pathogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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