Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Author:

Nilsen Aaron1,LaCrue Alexis N.2,White Karen L.3,Forquer Isaac P.1,Cross R. Matthew4,Marfurt Jutta5,Mather Michael W.6,Delves Michael J.7,Shackleford David M.3,Saenz Fabian E.2,Morrisey Joanne M.6,Steuten Jessica3,Mutka Tina2,Li Yuexin1,Wirjanata Grennady5,Ryan Eileen3,Duffy Sandra8,Kelly Jane Xu1,Sebayang Boni F.9,Zeeman Anne-Marie10,Noviyanti Rintis9,Sinden Robert E.7,Kocken Clemens H. M.10,Price Ric N.511,Avery Vicky M.8,Angulo-Barturen Iñigo12,Jiménez-Díaz María Belén12,Ferrer Santiago12,Herreros Esperanza12,Sanz Laura M.12,Gamo Francisco-Javier12,Bathurst Ian13,Burrows Jeremy N.13,Siegl Peter14,Guy R. Kiplin15,Winter Rolf W.1,Vaidya Akhil B.6,Charman Susan A.3,Kyle Dennis E.2,Manetsch Roman4,Riscoe Michael K.116

Affiliation:

1. Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA.

2. Department of Global Health, College of Public Health, 3720 Spectrum Boulevard (Suite 304), Tampa, FL 33612, USA.

3. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

4. Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620–5250, USA.

5. Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, NT 0811, Australia.

6. Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

7. Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.

8. Eskitis Institute for Cell and Molecular Therapies, Brisbane Innovation Park, Nathan Campus, Griffith University, Brisbane, Queensland 4111, Australia.

9. Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta 10430, Indonesia.

10. Department of Parasitology, Biomedical Primate Research Centre, P. O. Box 3306, 2280 GH Rijswijk, the Netherlands.

11. Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.

12. GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.

13. Medicines for Malaria Venture, 20, route de Pré-Bois, P. O. Box 1826, 1215 Geneva 15, Switzerland.

14. Siegl Pharma Consulting LLC, Blue Bell, PA 19422, USA.

15. Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105–3678, USA.

16. Department of Molecular Microbiology and Immunology, 3181 Sam Jackson Boulevard, Portland, OR 97239, USA.

Abstract

ELQ-300, an investigational drug for treating and preventing malaria, shows potent transmission-blocking activity in rodent models of malaria.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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