Denervation suppresses gastric tumorigenesis

Author:

Zhao Chun-Mei1,Hayakawa Yoku2,Kodama Yosuke1,Muthupalani Sureshkumar3,Westphalen Christoph B.24,Andersen Gøran T.15,Flatberg Arnar1,Johannessen Helene1,Friedman Richard A.6,Renz Bernhard W.2,Sandvik Arne K.17,Beisvag Vidar1,Tomita Hiroyuki8,Hara Akira8,Quante Michael9,Li Zhishan10,Gershon Michael D.10,Kaneko Kazuhiro11,Fox James G.3,Wang Timothy C.2,Chen Duan1

Affiliation:

1. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7491, Norway.

2. Division of Digestive and Liver Diseases, Columbia University College of Physicians and Surgeons, New York, NY 10032–3802, USA.

3. Division of Comparative Medicine, Massachusetts Institute of Technology, Boston, MA 02139, USA.

4. Medizinische Klinik III, Klinikum der Universität München, Campus Groβhadern, 81377 München, Germany.

5. Department of Surgery, St. Olavs University Hospital, Trondheim 7006, Norway.

6. Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

7. Department of Gastrointestinal and Liver Diseases, St. Olavs University Hospital, Trondheim 7006, Norway.

8. Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1112, Japan.

9. II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München 81675, Germany.

10. Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

11. Department of Gastroenterology and Endoscopy Division, National Cancer Center Hospital East, Chiba 277-8577, Japan.

Abstract

Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

2. Intestinal Epithelial Stem/Progenitor Cells Are Controlled by Mucosal Afferent Nerves

3. Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain;Mattingly R. R.;Mol. Cell. Biol.,1994

4. Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer

5. Muscarinic receptors and ligands in cancer

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