Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection

Author:

Urbanowicz Richard A.1234ORCID,Tsoleridis Theocharis123ORCID,Jackson Hannah J.5ORCID,Cusin Lola5ORCID,Duncan Joshua D.123ORCID,Chappell Joseph G.123ORCID,Tarr Alexander W.123ORCID,Nightingale Jessica67,Norrish Alan R.26ORCID,Ikram Adeel67ORCID,Marson Ben67ORCID,Craxford Simon J.67,Kelly Anthony26ORCID,Aithal Guruprasad P.2ORCID,Vijay Amrita26,Tighe Patrick J.5ORCID,Ball Jonathan K.123ORCID,Valdes Ana M.26ORCID,Ollivere Benjamin J.267ORCID

Affiliation:

1. Wolfson Centre for Global Virus Research, University of Nottingham, A Floor, West Block, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.

2. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.

3. School of Life Sciences, University of Nottingham, A Floor, West Block, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.

4. Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK.

5. School of Life Sciences, University of Nottingham, Life Sciences Building, University Park Campus, Nottingham NG7 2RD, UK.

6. Injury, Inflammation & Recovery Sciences, School of Medicine, University of Nottingham, C Floor, West Block, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.

7. Trauma and Orthopaedics, University Hospitals Nottingham, C Floor, West Block, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, UK.

Abstract

Antibody responses to SARS-CoV-2 variants increase after two doses of BNT162b2 vaccine in both previously infected and naïve individuals.

Funder

Horizon 2020 Framework Programme

Medical Research Council

NIHR Nottingham Biomedical Research Centre

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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