Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Author:

Cho Hyeseon1ORCID,Gonzales-Wartz Kristina Kay2ORCID,Huang Deli3,Yuan Meng4ORCID,Peterson Mary1ORCID,Liang Janie5,Beutler Nathan3ORCID,Torres Jonathan L.4ORCID,Cong Yu5,Postnikova Elena5,Bangaru Sandhya4ORCID,Talana Chloe Adrienna6ORCID,Shi Wei6ORCID,Yang Eun Sung6ORCID,Zhang Yi6ORCID,Leung Kwanyee6ORCID,Wang Lingshu6ORCID,Peng Linghang3ORCID,Skinner Jeff1ORCID,Li Shanping1ORCID,Wu Nicholas C.4ORCID,Liu Hejun4ORCID,Dacon Cherrelle2ORCID,Moyer Thomas7ORCID,Cohen Melanie7ORCID,Zhao Ming8ORCID,Lee Frances Eun-Hyung9ORCID,Weinberg Rona S.10ORCID,Douagi Iyadh7,Gross Robin5,Schmaljohn Connie5ORCID,Pegu Amarendra6ORCID,Mascola John R.6ORCID,Holbrook Michael5ORCID,Nemazee David3ORCID,Rogers Thomas F.311ORCID,Ward Andrew B.4ORCID,Wilson Ian A.412ORCID,Crompton Peter D.1ORCID,Tan Joshua2ORCID

Affiliation:

1. Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

2. Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

3. Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.

4. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

5. Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

6. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

7. Flow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

8. Protein Chemistry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

9. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA 30322, USA.

10. New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.

11. Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

12. Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA, 92037, USA.

Abstract

Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants of concern and wild-type virus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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