A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy

Author:

Weedall Gareth D.12,Mugenzi Leon M. J.34,Menze Benjamin D.134,Tchouakui Magellan34,Ibrahim Sulaiman S.15,Amvongo-Adjia Nathalie46ORCID,Irving Helen1,Wondji Murielle J.134,Tchoupo Micareme34,Djouaka Rousseau7,Riveron Jacob M.134ORCID,Wondji Charles S.134ORCID

Affiliation:

1. Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

2. School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool L3 3AF, U.K.

3. LSTM Research Unit at the Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.

4. Centre for Research in Infectious Diseases (CRID), P.O. Box 13591, Yaoundé, Cameroon.

5. Department of Biochemistry, Bayero University, PMB 3011, Kano, Nigeria.

6. Centre for Medical Research, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 13033, Yaoundé, Cameroon.

7. International Institute of Tropical Agriculture (IITA), Cotonou 08 BP 0932, Benin.

Abstract

A cytochrome P450 DNA marker in a major mosquito vector of malaria indicates that pyrethroid resistance reduces bednet efficacy.

Funder

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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