ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma-Reference-Cited by-同舟云学术

ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma

Published:2021-01-20 Issue:577 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Khanna Prateek¹²^ORCID,Soh Hong Jie³^ORCID,Chen Chun-Hau¹^ORCID,Saxena Ruchi¹^ORCID,Amin Seema¹,Naughton Maura³^ORCID,Joslin Patrick Neset¹,Moore Andrew³,Bakouny Ziad⁴^ORCID,O’Callaghan Carol³^ORCID,Catalano Paul⁴^ORCID,Signoretti Sabina⁵⁶^ORCID,McKay Rana⁴,Choueiri Toni K.⁴^ORCID,Bhasin Manoj⁷,Walther Thomas³⁸^ORCID,Bhatt Rupal S.¹^ORCID

Affiliation:

1. Division of Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA 02138, USA.

3. Department of Pharmacology and Therapeutics, School of Medicine and School of Pharmacy, University College Cork, Cork T12 K8AF, Ireland.

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

5. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

6. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

7. Division of Interdisciplinary Medicine and Biotechnology and Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

8. Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald 17489, Germany.

Abstract

ACE2 is protective against renal cancer, and its down-modulation by inhibitors of VEGF receptor signaling may mediate resistance to such inhibitors.

Funder

NIH Clinical Center

DFCI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Renal cell carcinoma