Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Author:

Freund Natalia T.1,Wang Haoqing2,Scharf Louise2,Nogueira Lilian1,Horwitz Joshua A.1,Bar-On Yotam1,Golijanin Jovana1,Sievers Stuart A.2,Sok Devin3,Cai Hui4,Cesar Lorenzi Julio C.1,Halper-Stromberg Ariel1,Toth Ildiko5,Piechocka-Trocha Alicja5,Gristick Harry B.2,van Gils Marit J.6,Sanders Rogier W.6,Wang Lai-Xi4,Seaman Michael S.7,Burton Dennis R.35,Gazumyan Anna1,Walker Bruce D.58,West Anthony P.2,Bjorkman Pamela J.2,Nussenzweig Michel C.18

Affiliation:

1. Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.

2. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

3. Department of Immunology and Microbial Science, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, and International AIDS Vaccine Initiative Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.

4. Department of Chemistry and Biochemistry, University of Maryland, 8051 Regents Drive, College Park, MD 20742, USA.

5. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02129, USA.

6. Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

7. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

8. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Three new potent neutralizing antibodies neutralize autologous HIV-1 strains and contribute to viral control in an HIV-1 controller.

Funder

Robertson Foundation

Rockefeller University

Bill and Melinda Gates Foundation

Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery Scripps

NIH HIV Vaccine Research and Design

NIH

Gordon and Betty Moore Foundation

Melinda and Bill Gates Foundation Collaboration for AIDS Vaccine Discovery

CHRP

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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