Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake-Reference-Cited by-同舟云学术

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

Published:2017-06-07 Issue:393 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liang Frank¹²^ORCID,Lindgren Gustaf¹²^ORCID,Sandgren Kerrie J.¹,Thompson Elizabeth A.¹²,Francica Joseph R.³,Seubert Anja⁴^ORCID,De Gregorio Ennio⁴,Barnett Susan⁵,O’Hagan Derek T.⁵,Sullivan Nancy J.³,Koup Richard A.³,Seder Robert A.³,Loré Karin¹²^ORCID

Affiliation:

1. Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

2. Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

3. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. GSK Vaccines, Siena, Italy.

5. GSK Vaccines, Rockville, MD 20850, USA.

Abstract

Vaccine responses are initiated in vaccine-draining lymph nodes and depend on the efficiency by which adjuvants influence antigen uptake.

Funder

Swedish Research Council for Health, Working Life and Welfare

Swedish Research Council

Swedish Govermental Agency for Innovation Systems