Antigenic competition in CD4 + T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial

Author:

Kallas Esper G.1ORCID,Grunenberg Nicole A.2ORCID,Yu Chenchen2,Manso Bryce2ORCID,Pantaleo Giuseppe3,Casapia Martin4ORCID,Baden Lindsey R.5,Valencia Javier6ORCID,Sobieszczyk Magdalena7,Van Tieu Hong8ORCID,Allen Mary9ORCID,Hural John2,Graham Barney S.10ORCID,Kublin James2ORCID,Gilbert Peter B.2ORCID,Corey Lawrence2ORCID,Goepfert Paul A.11ORCID,McElrath M. Juliana2121314ORCID,Johnson R. Paul15ORCID,Huang Yunda2ORCID,Frahm Nicole212ORCID

Affiliation:

1. Division of Clinical Immunology and Allergy, University of São Paulo, São Paulo 05508, Brazil.

2. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

3. Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.

4. Asociación Civil Selva Amazónica, Iquitos 16002, Peru.

5. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

6. Asociación Civil Impacta Salud Y Educación, Lima 15063, Peru.

7. Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.

8. Laboratory of Infectious Disease Prevention, New York Blood Center, New York, NY 10065, USA.

9. Division of AIDS, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

10. Vaccine Research Center, NIH, Bethesda, MD 20892, USA.

11. Division of Infectious Disease and Department of Surgery, Division of Gastroenterology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

12. Department of Global Health, University of Washington, Seattle, WA 98195, USA.

13. Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

14. Department of Medicine, University of Washington, Seattle, WA 98195, USA.

15. Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA 30322, USA.

Abstract

Antigenic competition in CD4 + T cell responses occurs in HIV vaccine recipients.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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