LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

Author:

Wan JingHong1ORCID,Weiss Emmanuel12,Ben Mkaddem Sanae1ORCID,Mabire Morgane1,Choinier Pierre-Marie12,Picq Olivia12,Thibault-Sogorb Tristan12,Hegde Pushpa1ORCID,Pishvaie Dorsa3,Bens Marcelle1,Broer Linda1,Gilgenkrantz Hélène1,Moreau Richard13ORCID,Saveanu Loredana1ORCID,Codogno Patrice4,Monteiro Renato C.1,Lotersztajn Sophie1ORCID

Affiliation:

1. Université de Paris, Centre de Recherche sur l'Inflammation (CRI), INSERM, U1149, CNRS, ERL 8252, F-75018 Paris, France.

2. Department of Anesthesiology and Critical Care, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, F-92110 Clichy, France.

3. Department of Hepatology, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, F-92110, Clichy, France.

4. Université de Paris Institut Necker-Enfants malades (INEM), INSERM, U1151, CNRS UMR8223, F-75015 Paris, France.

Abstract

LC3-associated phagocytosis is a protective mechanism against inflammation, with antifibrogenic properties in the liver.

Funder

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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