The human tissue-resident CCR5 + T cell compartment maintains protective and functional properties during inflammation

Author:

Woodward Davis Amanda S.1ORCID,Roozen Hayley N.1ORCID,Dufort Matthew J.2ORCID,DeBerg Hannah A.2ORCID,Delaney Martha A.3ORCID,Mair Florian1ORCID,Erickson Jami R.1ORCID,Slichter Chloe K.14,Berkson Julia D.1ORCID,Klock Alexis M.5ORCID,Mack Matthias6,Lwo Yu7ORCID,Ko Alexander7ORCID,Brand Rhonda M.89ORCID,McGowan Ian1011ORCID,Linsley Peter S.2ORCID,Dixon Douglas R.7ORCID,Prlic Martin1412ORCID

Affiliation:

1. Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.

2. Systems Immunology Division, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

3. Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.

4. Department of Global Health, University of Washington, Seattle, WA 98195, USA.

5. Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

6. Department of Internal Medicine–Nephrology, University Hospital Regensburg, 93053 Regensburg, Germany.

7. Department of Periodontics, University of Washington, Seattle, WA 98195, USA.

8. Department of Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

9. Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

10. University of Miami Miller School of Medicine, Miami, FL 33136, USA.

11. Orion Biotechnology, Ottawa, ON, K1S 1N4, Canada.

12. Department of Immunology, University of Washington, Seattle, WA 98109, USA.

Abstract

Human CD69 + CCR5 + T cells in mucosal tissues are poised to maintain barrier immunity in healthy and inflamed tissues.

Funder

National Institutes of Health

Fred Hutchinson Cancer Research Center

International Society for Advancement of Cytometry

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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